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                                       Hisaya Kakinuma

<Aim>

I found the importance of the biological functional assays in the animals, not only in the culture cells. So I would like to make the conditions in which an interesting factor functions genetically and molecular biologically through the advantages of the model animals.


<Research>
Study of the molecular mechanism of FGF signaling positive regulator Canopy1

In zebrafish, Saposine-like protein Canopy1 contributes to a positive-feedback loop of FGF signaling in the MHB. But the precise molecular mechanism remains unknown. Canopy1 protein might be involved in FGF signaling through the regulation of the lipid rafts structures. We would like to clarify this quality control mechanism with the molecular biological approaches.