Brain functional asymmetry is substantially interesting, especially in human brain, whereas the research is limited for various reasons. Zebrafish, an animal model famous for easy breeding and amenable to advanced manipulation techniques, can significantly contribute to facilitate understanding of brain asymmetry. Through this study, I'd like to make an "innovative discovery" on the brain functional asymmetry.
Habenula, paired dorsal diencephalic nuclei, reveals left-right asymmetry
in zebrafish. In addition to the interest of the physiological function
of the nuclei, the asymmetrical structure is also fascinating as a biological
model of functional asymmetry of brain among whole vertebrates. Although
the nuclei has been analyzed for a long time, especially in mammals, molecular
mechanism underlying the functions have not been revealed. We are focusing
on the molecules expressed asymmetrically in zebrafish habenula nuclei.
Taking advantage of their specific expression patterns, I am now working
on genetic engineering of zebrarish to manipulate gene expression in the